Assay Detail
Binding
CHEMBL3396870
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Inhibition of Bcl-xL/Bim (unknown origin) by ELISA
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Bcl-xL/Bcl-2-like protein 11 (CHEMBL3883287) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.37 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 8.37 |
| CHEMBL3393641 | — | — | 1 | 6.30 |
| CHEMBL3393632 | — | — | 1 | 6.22 |
| CHEMBL3393631 | — | — | 1 | 6.22 |
| CHEMBL3393639 | — | — | 1 | 6.10 |
| CHEMBL3393630 | — | — | 1 | 5.92 |
| CHEMBL3393638 | — | — | 1 | 5.80 |
| CHEMBL3393627 | — | — | 1 | 5.68 |
| CHEMBL3393623 | — | — | 1 | 5.60 |
| CHEMBL3393625 | — | — | 1 | 5.46 |
| CHEMBL3393640 | — | — | 1 | 5.42 |
| CHEMBL3393626 | — | — | 1 | 5.41 |
| CHEMBL3393624 | — | — | 1 | 5.25 |
| CHEMBL3393653 | — | — | 1 | 5.10 |
| CHEMBL3393643 | — | — | 1 | 5.09 |
| CHEMBL3393648 | — | — | 1 | 5.04 |
| CHEMBL3393645 | — | — | 1 | 5.02 |
| CHEMBL3393622 | — | — | 1 | 5.01 |
| CHEMBL3393646 | — | — | 1 | 5.00 |
| CHEMBL3393649 | — | — | 1 | 4.88 |
| CHEMBL3393636 | — | — | 1 | 4.85 |
| CHEMBL3393621 | — | — | 1 | 4.79 |
| CHEMBL3393647 | — | — | 1 | 4.74 |
| CHEMBL3393650 | — | — | 1 | 4.67 |
| CHEMBL3393634 | — | — | 1 | 4.56 |
| CHEMBL3393651 | — | — | 1 | 4.36 |
| CHEMBL3393652 | — | — | 1 | 4.19 |
| CHEMBL3393644 | — | — | 1 | - |
| CHEMBL3393629 | — | — | 1 | - |
| CHEMBL3393642 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL3393641 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3393632 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3393631 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3393639 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3393630 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3393638 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3393627 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3393623 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3393625 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3393640 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3393626 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3393624 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3393653 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL3393643 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL3393648 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3393645 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL3393622 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL3393646 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL3393649 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL3393636 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3393621 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL3393647 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL3393650 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL3393634 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL3393651 | — | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL3393652 | — | IC50 | = | 64900.0 | nM | 4.19 |
| CHEMBL3393644 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3393629 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3393642 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3393628 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3393633 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3393637 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3393635 | — | IC50 | > | 100000.0 | nM | - |