Assay Detail
Binding
CHEMBL3398677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of human PPARgamma ligand binding domain expressed in COS7 cells by dual luciferase reporter gene assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 5.43 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3397709 | — | — | 1 | 6.14 |
| CHEMBL3397726 | — | — | 1 | 5.90 |
| CHEMBL3397716 | — | — | 1 | 5.68 |
| CHEMBL3397727 | — | — | 1 | 5.67 |
| CHEMBL3397718 | — | — | 1 | 5.59 |
| CHEMBL3397724 | — | — | 1 | 5.42 |
| CHEMBL3397717 | — | — | 1 | 5.33 |
| CHEMBL3397715 | — | — | 1 | 5.29 |
| CHEMBL1171834 | — | — | 1 | 5.18 |
| CHEMBL461883 | — | — | 1 | 5.08 |
| CHEMBL3397710 | — | — | 1 | 4.93 |
| CHEMBL3397711 | — | — | 1 | 4.89 |
| CHEMBL3397712 | — | — | 1 | - |
| CHEMBL3397713 | — | — | 1 | - |
| CHEMBL3397714 | — | — | 1 | - |
| CHEMBL3397719 | — | — | 1 | - |
| CHEMBL3397720 | — | — | 1 | - |
| CHEMBL3397722 | — | — | 1 | - |
| CHEMBL3397723 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3397709 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL3397726 | — | EC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL3397716 | — | EC50 | = | 2110.0 | nM | 5.68 |
| CHEMBL3397727 | — | EC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL3397718 | — | EC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL3397724 | — | EC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL3397717 | — | EC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL3397715 | — | EC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL1171834 | — | EC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL461883 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3397710 | — | EC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL3397711 | — | EC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL3397712 | — | EC50 | - | — | - | |
| CHEMBL3397713 | — | EC50 | - | — | - | |
| CHEMBL3397714 | — | EC50 | - | — | - | |
| CHEMBL3397719 | — | EC50 | - | — | - | |
| CHEMBL3397720 | — | EC50 | - | — | - | |
| CHEMBL3397722 | — | EC50 | - | — | - | |
| CHEMBL3397723 | — | EC50 | - | — | - |