Assay Detail
Binding
CHEMBL3398679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-LO in human human PMNL assessed as reduction in 5-LO product formation pre-incubated for 15 mins before addition of arachidonic acid substrate by HPLC analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.14 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3397723 | — | — | 1 | 6.70 |
| CHEMBL3397721 | — | — | 1 | 6.70 |
| CHEMBL1819479 | — | — | 1 | 6.70 |
| CHEMBL3397726 | — | — | 1 | 6.60 |
| CHEMBL3397717 | — | — | 1 | 6.52 |
| CHEMBL3397716 | — | — | 1 | 6.52 |
| CHEMBL3397728 | — | — | 1 | 6.30 |
| CHEMBL3397715 | — | — | 1 | 6.30 |
| CHEMBL3397710 | — | — | 1 | 6.26 |
| CHEMBL461883 | — | — | 1 | 6.22 |
| CHEMBL3397719 | — | — | 1 | 6.16 |
| CHEMBL3397711 | — | — | 1 | 6.12 |
| CHEMBL1171834 | — | — | 1 | 6.10 |
| CHEMBL3397720 | — | — | 1 | 6.05 |
| CHEMBL3397724 | — | — | 1 | 6.05 |
| CHEMBL3397727 | — | — | 1 | 5.77 |
| CHEMBL3397709 | — | — | 1 | 5.68 |
| CHEMBL3397718 | — | — | 1 | 5.64 |
| CHEMBL3397708 | — | — | 1 | 5.24 |
| CHEMBL3397722 | — | — | 1 | 5.17 |
| CHEMBL3397713 | — | — | 1 | - |
| CHEMBL3397714 | — | — | 1 | - |
| CHEMBL3397712 | — | — | 1 | - |
| CHEMBL3397725 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3397723 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3397721 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1819479 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3397726 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3397717 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3397716 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3397728 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3397715 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3397710 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL461883 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3397719 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3397711 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL1171834 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3397720 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3397724 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3397727 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3397709 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3397718 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3397708 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL3397722 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL3397713 | — | IC50 | - | — | - | |
| CHEMBL3397714 | — | IC50 | - | — | - | |
| CHEMBL3397712 | — | IC50 | - | — | - | |
| CHEMBL3397725 | — | IC50 | - | — | - |