Assay Detail
Binding
CHEMBL3398686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human purified MPG pre-incubated with compound for 10 mins followed by addition of 1,N6 ethenoadenine containing 32P-labeled duplex oligonucleotide substrates by gel-based excision activity assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Naturally occurring polyphenol, morin hydrate, inhibits enzymatic activity of N-methylpurine DNA glycosylase, a DNA repair enzyme with various roles in human disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.85 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | — | 1 | 6.70 |
| CHEMBL1417019 | MITOXANTRONE HYDROCHLORIDE | 4.0 | 1 | 5.60 |
| CHEMBL1512355 | — | — | 1 | 5.58 |
| CHEMBL51483 | GOSSYPOL | 3.0 | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275938 | AURINTRICARBOXYLIC ACID | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1417019 | MITOXANTRONE HYDROCHLORIDE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1512355 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL51483 | GOSSYPOL | IC50 | = | 3000.0 | nM | 5.52 |