Assay Detail
Binding
CHEMBL3398873
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as Ca2+ influx by Fluo-4 dye based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.78 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL294199 | CAPSAICIN | 4.0 | 1 | 8.28 |
| CHEMBL3398239 | — | — | 1 | 5.26 |
| CHEMBL3398238 | — | — | 1 | 5.16 |
| CHEMBL3398240 | — | — | 1 | 4.43 |
| CHEMBL3398241 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL294199 | CAPSAICIN | EC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3398239 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3398238 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL3398240 | — | EC50 | = | 37500.0 | nM | 4.43 |
| CHEMBL3398241 | — | EC50 | - | — | - |