Assay Detail
Binding
CHEMBL3398879
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of STEP (unknown origin) pre-incubated for 10 mins before addition of p-nitrophenyl phosphate substrate in presence of 1 mM GSH
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 5 (CHEMBL2007628) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.70 | 5.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3398242 | — | — | 1 | 5.06 |
| CHEMBL3398246 | — | — | 1 | 4.82 |
| CHEMBL3398244 | — | — | 1 | 4.77 |
| CHEMBL3398243 | — | — | 1 | 4.77 |
| CHEMBL3398250 | — | — | 1 | 4.70 |
| CHEMBL3398247 | — | — | 1 | 4.62 |
| CHEMBL3398249 | — | — | 1 | 4.57 |
| CHEMBL3398245 | — | — | 1 | 4.48 |
| CHEMBL3398251 | — | — | 1 | 4.47 |
| CHEMBL3398248 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3398242 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL3398246 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3398244 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3398243 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3398250 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3398247 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3398249 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL3398245 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3398251 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL3398248 | — | IC50 | > | 50000.0 | nM | - |