Assay Detail
Binding
CHEMBL3398941
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Inhibition of Trypanosoma cruzi trypanothione reductase assessed as reduction of trypanothione disulfide by spectrophotometrically
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.16 | 6.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3398189 | — | — | 1 | 6.59 |
| CHEMBL378650 | — | — | 1 | 5.40 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 1 | 5.19 |
| CHEMBL3398188 | — | — | 1 | 5.12 |
| CHEMBL3398187 | — | — | 1 | 4.55 |
| CHEMBL3398186 | — | — | 1 | 4.09 |
| CHEMBL332939 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3398189 | — | Ki | = | 255.0 | nM | 6.59 |
| CHEMBL378650 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL415 | CLOMIPRAMINE | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL3398188 | — | Ki | = | 7620.0 | nM | 5.12 |
| CHEMBL3398187 | — | Ki | = | 27900.0 | nM | 4.55 |
| CHEMBL3398186 | — | Ki | = | 81600.0 | nM | 4.09 |
| CHEMBL332939 | — | Ki | = | 136000.0 | nM | - |