Assay Detail
Functional
CHEMBL3399094
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay in presence of NQO1 inhibitor dicoumarol
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.52 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3398291 | — | — | 1 | 4.77 |
| CHEMBL394882 | NOR-BETA-LAPACHONE | — | 1 | 4.70 |
| CHEMBL3398290 | — | — | 1 | 4.62 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 4.60 |
| CHEMBL2158088 | — | — | 1 | 4.52 |
| CHEMBL3398292 | — | — | 1 | 4.47 |
| CHEMBL3398293 | — | — | 1 | 4.39 |
| CHEMBL3398294 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3398291 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL394882 | NOR-BETA-LAPACHONE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3398290 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2158088 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3398292 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL3398293 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL3398294 | — | IC50 | = | 79000.0 | nM | 4.10 |