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Assay Detail

CHEMBL3399189

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Functional
Antiproliferative activity against human HepG2 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Isolation and cytotoxicity evaluation of taxanes from the barks of Taxus wallichiana var. mairei.
Sun ZH, Chen Y, Guo YQ, Qiu J, Zhu CG, Jin J, Tang GH, Bu XZ, Yin S.
Bioorg Med Chem Lett (2015) 25 : 1240 -1243
PubMed 25682561 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.10 8.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL428647 PACLITAXEL 4.0 1 8.05
CHEMBL305522 CEPHALOMANNINE 1 7.70
CHEMBL500852 1 7.02
CHEMBL3398369 1 5.92
CHEMBL3398367 1 5.52
CHEMBL3398370 1 5.41
CHEMBL3398368 1 5.24
CHEMBL3398366 1 5.21
CHEMBL445031 1 4.82
CHEMBL77199 1 -
CHEMBL3397058 1 -
CHEMBL448698 TAXININE M 1 -
CHEMBL3398371 1 -
CHEMBL393912 1 -
CHEMBL288043 BACCATIN III 1 -
CHEMBL302290 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL428647 PACLITAXEL IC50 = 9.0 nM 8.05
CHEMBL305522 CEPHALOMANNINE IC50 = 20.0 nM 7.70
CHEMBL500852 IC50 = 95.0 nM 7.02
CHEMBL3398369 IC50 = 1200.0 nM 5.92
CHEMBL3398367 IC50 = 3000.0 nM 5.52
CHEMBL3398370 IC50 = 3900.0 nM 5.41
CHEMBL3398368 IC50 = 5800.0 nM 5.24
CHEMBL3398366 IC50 = 6100.0 nM 5.21
CHEMBL445031 IC50 = 15000.0 nM 4.82
CHEMBL77199 IC50 > 25000.0 nM -
CHEMBL3397058 IC50 > 25000.0 nM -
CHEMBL448698 TAXININE M IC50 > 25000.0 nM -
CHEMBL3398371 IC50 - -
CHEMBL393912 IC50 - -
CHEMBL288043 BACCATIN III IC50 - -
CHEMBL302290 IC50 - -