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Assay Detail

CHEMBL3399347

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Functional
Antileishmanial activity against promastigote stage of Leishmania amazonensis WHOM/BR/75/JOSEFA after 72 hrs by hemocytometry
ChEMBL ↗
84
Total Activities
84
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania amazonensis
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania amazonensis (CHEMBL612877) ↗
Type ORGANISM
Organism Leishmania amazonensis

Publication

Synthesis and biological evaluation of novel 2,3-disubstituted quinoxaline derivatives as antileishmanial and antitrypanosomal agents.
Cogo J, Kaplum V, Sangi DP, Ueda-Nakamura T, Corrêa AG, Nakamura CV.
Eur J Med Chem (2015) 90 : 107 -123
PubMed 25461316 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 84 4.90 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3397141 — — 1 7.00
CHEMBL3397145 — — 1 6.70
CHEMBL3397144 — — 1 6.70
CHEMBL267345 AMPHOTERICIN B 4.0 1 6.12
CHEMBL3397140 — — 1 6.10
CHEMBL3397254 — — 1 6.10
CHEMBL3397256 — — 1 5.85
CHEMBL3397142 — — 1 5.80
CHEMBL3397253 — — 1 5.80
CHEMBL3397133 — — 1 5.72
CHEMBL3397259 — — 1 5.72
CHEMBL3397257 — — 1 5.66
CHEMBL3397258 — — 1 5.60
CHEMBL3397243 — — 1 5.60
CHEMBL3397255 — — 1 5.58
CHEMBL3397247 — — 1 5.54
CHEMBL3397245 — — 1 5.54
CHEMBL3397244 — — 1 5.54
CHEMBL3397246 — — 1 5.54
CHEMBL3397143 — — 1 5.54
CHEMBL3397137 — — 1 5.28
CHEMBL3397139 — — 1 5.24
CHEMBL3397134 — — 1 5.21
CHEMBL3397267 — — 1 5.19
CHEMBL1452056 — — 1 5.05
CHEMBL1492174 — — 1 4.89
CHEMBL3397266 — — 1 4.87
CHEMBL3397250 — — 1 4.83
CHEMBL3397117 — — 1 4.71
CHEMBL302245 — — 1 4.68

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3397141 — IC50 = 100.0 nM 7.00
CHEMBL3397145 — IC50 = 200.0 nM 6.70
CHEMBL3397144 — IC50 = 200.0 nM 6.70
CHEMBL267345 AMPHOTERICIN B IC50 = 750.0 nM 6.12
CHEMBL3397140 — IC50 = 800.0 nM 6.10
CHEMBL3397254 — IC50 = 800.0 nM 6.10
CHEMBL3397256 — IC50 = 1400.0 nM 5.85
CHEMBL3397142 — IC50 = 1600.0 nM 5.80
CHEMBL3397253 — IC50 = 1600.0 nM 5.80
CHEMBL3397133 — IC50 = 1900.0 nM 5.72
CHEMBL3397259 — IC50 = 1900.0 nM 5.72
CHEMBL3397257 — IC50 = 2200.0 nM 5.66
CHEMBL3397258 — IC50 = 2500.0 nM 5.60
CHEMBL3397243 — IC50 = 2500.0 nM 5.60
CHEMBL3397255 — IC50 = 2600.0 nM 5.58
CHEMBL3397247 — IC50 = 2900.0 nM 5.54
CHEMBL3397143 — IC50 = 2900.0 nM 5.54
CHEMBL3397246 — IC50 = 2900.0 nM 5.54
CHEMBL3397244 — IC50 = 2900.0 nM 5.54
CHEMBL3397245 — IC50 = 2900.0 nM 5.54
CHEMBL3397137 — IC50 = 5300.0 nM 5.28
CHEMBL3397139 — IC50 = 5700.0 nM 5.24
CHEMBL3397134 — IC50 = 6200.0 nM 5.21
CHEMBL3397267 — IC50 = 6500.0 nM 5.19
CHEMBL1452056 — IC50 = 8900.0 nM 5.05
CHEMBL1492174 — IC50 = 12800.0 nM 4.89
CHEMBL3397266 — IC50 = 13600.0 nM 4.87
CHEMBL3397250 — IC50 = 14700.0 nM 4.83
CHEMBL3397117 — IC50 = 19700.0 nM 4.71
CHEMBL302245 — IC50 = 21100.0 nM 4.68
CHEMBL3397265 — IC50 = 20900.0 nM 4.68
CHEMBL3397234 — IC50 = 21500.0 nM 4.67
CHEMBL3397122 — IC50 = 21300.0 nM 4.67
CHEMBL3397252 — IC50 = 21200.0 nM 4.67
CHEMBL3397116 — IC50 = 21900.0 nM 4.66
CHEMBL3397138 — IC50 = 22200.0 nM 4.65
CHEMBL3397111 — IC50 = 24100.0 nM 4.62
CHEMBL3397121 — IC50 = 24700.0 nM 4.61
CHEMBL3397264 — IC50 = 24500.0 nM 4.61
CHEMBL3397240 — IC50 = 24400.0 nM 4.61
CHEMBL3397132 — IC50 = 24300.0 nM 4.61
CHEMBL3397237 — IC50 = 25200.0 nM 4.60
CHEMBL3397236 — IC50 = 27100.0 nM 4.57
CHEMBL3397235 — IC50 = 26900.0 nM 4.57
CHEMBL3397251 — IC50 = 27800.0 nM 4.56
CHEMBL3397239 — IC50 = 27600.0 nM 4.56
CHEMBL3397136 — IC50 = 28100.0 nM 4.55
CHEMBL3397110 — IC50 = 27900.0 nM 4.55
CHEMBL3397112 — IC50 = 28700.0 nM 4.54
CHEMBL3397109 — IC50 = 29600.0 nM 4.53