Assay Detail
Functional
CHEMBL3399398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against amastigote stage of Leishmania amazonensis WHOM/BR/75/JOSEFA infected in BALB/c mouse peritoneal macrophages after 72 hrs by Geimsa staining-based light microscopy
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania amazonensis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel 2,3-disubstituted quinoxaline derivatives as antileishmanial and antitrypanosomal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.30 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 6.40 |
| CHEMBL3397144 | — | — | 1 | 5.85 |
| CHEMBL3397141 | — | — | 1 | 5.82 |
| CHEMBL3397145 | — | — | 1 | 5.51 |
| CHEMBL3397140 | — | — | 1 | 5.34 |
| CHEMBL3397258 | — | — | 1 | 5.14 |
| CHEMBL3397243 | — | — | 1 | 4.89 |
| CHEMBL3397244 | — | — | 1 | 4.76 |
| CHEMBL3397247 | — | — | 1 | 4.70 |
| CHEMBL3397264 | — | — | 1 | 4.60 |
| CHEMBL3397253 | — | — | 1 | - |
| CHEMBL3397254 | — | — | 1 | - |
| CHEMBL3397255 | — | — | 1 | - |
| CHEMBL3397257 | — | — | 1 | - |
| CHEMBL3397259 | — | — | 1 | - |
| CHEMBL3397142 | — | — | 1 | - |
| CHEMBL1504404 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3397144 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3397141 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3397145 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3397140 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3397258 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3397243 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL3397244 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL3397247 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL3397264 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3397253 | — | IC50 | - | — | - | |
| CHEMBL3397254 | — | IC50 | - | — | - | |
| CHEMBL3397255 | — | IC50 | - | — | - | |
| CHEMBL3397257 | — | IC50 | - | — | - | |
| CHEMBL3397259 | — | IC50 | - | — | - | |
| CHEMBL3397142 | — | IC50 | - | — | - | |
| CHEMBL1504404 | — | IC50 | - | — | - |