Assay Detail
Binding
CHEMBL3399480
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGFR2 (unknown origin) using ATP measured luminescence by ADP-Glo Kinase assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of biphenyl-based VEGFR-2 inhibitors. Part 3: design, synthesis and 3D-QSAR studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.38 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 9.07 |
| CHEMBL3397933 | — | — | 1 | 8.70 |
| CHEMBL3397917 | — | — | 1 | 8.36 |
| CHEMBL3397935 | — | — | 1 | 8.31 |
| CHEMBL3397934 | — | — | 1 | 8.06 |
| CHEMBL3397920 | — | — | 1 | 8.03 |
| CHEMBL3397932 | — | — | 1 | 7.84 |
| CHEMBL3397918 | — | — | 1 | 7.82 |
| CHEMBL3397942 | — | — | 1 | 7.75 |
| CHEMBL3397923 | — | — | 1 | 7.64 |
| CHEMBL3397940 | — | — | 1 | 7.56 |
| CHEMBL3397928 | — | — | 1 | 7.50 |
| CHEMBL3397936 | — | — | 1 | 7.35 |
| CHEMBL3397931 | — | — | 1 | 7.27 |
| CHEMBL3397930 | — | — | 1 | 7.20 |
| CHEMBL3397915 | — | — | 1 | 7.16 |
| CHEMBL3397946 | — | — | 1 | 7.14 |
| CHEMBL3397944 | — | — | 1 | 7.11 |
| CHEMBL3397939 | — | — | 1 | 7.07 |
| CHEMBL3397924 | — | — | 1 | 7.02 |
| CHEMBL3397945 | — | — | 1 | 6.90 |
| CHEMBL3397937 | — | — | 1 | 6.89 |
| CHEMBL3397922 | — | — | 1 | 6.88 |
| CHEMBL3397941 | — | — | 1 | 6.80 |
| CHEMBL3397916 | — | — | 1 | 6.74 |
| CHEMBL3397929 | — | — | 1 | 6.67 |
| CHEMBL3397947 | — | — | 1 | 6.46 |
| CHEMBL3397927 | — | — | 1 | 6.44 |
| CHEMBL3397925 | — | — | 1 | 6.20 |
| CHEMBL3397943 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL3397933 | — | IC50 | = | 2.02 | nM | 8.70 |
| CHEMBL3397917 | — | IC50 | = | 4.38 | nM | 8.36 |
| CHEMBL3397935 | — | IC50 | = | 4.86 | nM | 8.31 |
| CHEMBL3397934 | — | IC50 | = | 8.74 | nM | 8.06 |
| CHEMBL3397920 | — | IC50 | = | 9.41 | nM | 8.03 |
| CHEMBL3397932 | — | IC50 | = | 14.48 | nM | 7.84 |
| CHEMBL3397918 | — | IC50 | = | 15.04 | nM | 7.82 |
| CHEMBL3397942 | — | IC50 | = | 17.85 | nM | 7.75 |
| CHEMBL3397923 | — | IC50 | = | 22.85 | nM | 7.64 |
| CHEMBL3397940 | — | IC50 | = | 27.58 | nM | 7.56 |
| CHEMBL3397928 | — | IC50 | = | 31.98 | nM | 7.50 |
| CHEMBL3397936 | — | IC50 | = | 44.32 | nM | 7.35 |
| CHEMBL3397931 | — | IC50 | = | 54.26 | nM | 7.27 |
| CHEMBL3397930 | — | IC50 | = | 62.52 | nM | 7.20 |
| CHEMBL3397915 | — | IC50 | = | 69.4 | nM | 7.16 |
| CHEMBL3397946 | — | IC50 | = | 71.89 | nM | 7.14 |
| CHEMBL3397944 | — | IC50 | = | 77.45 | nM | 7.11 |
| CHEMBL3397939 | — | IC50 | = | 85.32 | nM | 7.07 |
| CHEMBL3397924 | — | IC50 | = | 94.69 | nM | 7.02 |
| CHEMBL3397945 | — | IC50 | = | 125.82 | nM | 6.90 |
| CHEMBL3397937 | — | IC50 | = | 129.25 | nM | 6.89 |
| CHEMBL3397922 | — | IC50 | = | 130.17 | nM | 6.88 |
| CHEMBL3397941 | — | IC50 | = | 158.46 | nM | 6.80 |
| CHEMBL3397916 | — | IC50 | = | 182.82 | nM | 6.74 |
| CHEMBL3397929 | — | IC50 | = | 214.87 | nM | 6.67 |
| CHEMBL3397947 | — | IC50 | = | 344.61 | nM | 6.46 |
| CHEMBL3397927 | — | IC50 | = | 359.63 | nM | 6.44 |
| CHEMBL3397925 | — | IC50 | = | 624.66 | nM | 6.20 |
| CHEMBL3397943 | — | IC50 | - | — | - | |
| CHEMBL3397938 | — | IC50 | - | — | - | |
| CHEMBL3397919 | — | IC50 | - | — | - | |
| CHEMBL3397921 | — | IC50 | - | — | - | |
| CHEMBL3397926 | — | IC50 | - | — | - |