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Assay Detail

CHEMBL3399617

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant MAO-B assessed as kynuramine oxidation to 4-hydroxyquinoline formation by spectrofluorometric analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibition of monoamine oxidase by indole-5,6-dicarbonitrile derivatives.
Chirkova ZV, Kabanova MV, Filimonov SI, Abramov IG, Petzer A, Petzer JP, Firgang SI, Suponitsky KY.
Bioorg Med Chem Lett (2015) 25 : 1206 -1211
PubMed 25701250 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.60 8.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2204752 1 8.32
CHEMBL3398531 1 7.77
CHEMBL3398530 1 7.70
CHEMBL279390 LAZABEMIDE 2.0 1 7.04
CHEMBL3398529 1 6.84
CHEMBL3398534 1 6.19
CHEMBL3398532 1 5.90
CHEMBL3398526 1 5.82
CHEMBL3398527 1 5.54
CHEMBL3398525 1 4.92
CHEMBL3398524 1 -
CHEMBL3398523 1 -
CHEMBL3398522 1 -
CHEMBL3398533 1 -
CHEMBL3398528 1 -
CHEMBL18116 TOLOXATONE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2204752 IC50 = 4.8 nM 8.32
CHEMBL3398531 IC50 = 17.0 nM 7.77
CHEMBL3398530 IC50 = 20.0 nM 7.70
CHEMBL279390 LAZABEMIDE IC50 = 91.0 nM 7.04
CHEMBL3398529 IC50 = 144.0 nM 6.84
CHEMBL3398534 IC50 = 642.0 nM 6.19
CHEMBL3398532 IC50 = 1270.0 nM 5.90
CHEMBL3398526 IC50 = 1520.0 nM 5.82
CHEMBL3398527 IC50 = 2860.0 nM 5.54
CHEMBL3398525 IC50 = 11900.0 nM 4.92
CHEMBL3398524 IC50 > 100000.0 nM -
CHEMBL3398523 IC50 > 100000.0 nM -
CHEMBL3398522 IC50 > 100000.0 nM -
CHEMBL3398533 IC50 > 100000.0 nM -
CHEMBL3398528 IC50 > 100000.0 nM -
CHEMBL18116 TOLOXATONE IC50 - -