Assay Detail
Functional
CHEMBL3399748
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Antiviral activity against HCV genotype 1a infected in human HuH7 cells by replicon based assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 5.26 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223482 | — | — | 1 | 6.22 |
| CHEMBL438605 | — | — | 1 | 5.60 |
| CHEMBL3398124 | — | — | 1 | 5.54 |
| CHEMBL2031681 | — | — | 1 | 4.82 |
| CHEMBL3309899 | — | — | 1 | 4.12 |
| CHEMBL510394 | — | — | 1 | - |
| CHEMBL3309900 | — | — | 1 | - |
| CHEMBL3398123 | — | — | 1 | - |
| CHEMBL3398122 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223482 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL438605 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3398124 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2031681 | — | EC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL3309899 | — | EC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL510394 | — | EC50 | > | 89000.0 | nM | - |
| CHEMBL3309900 | — | EC50 | > | 89000.0 | nM | - |
| CHEMBL3398123 | — | EC50 | > | 89000.0 | nM | - |
| CHEMBL3398122 | — | EC50 | > | 89000.0 | nM | - |