Assay Detail
Binding
CHEMBL3399863
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Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MGC-803 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel pyrazole-5-carboxamide and pyrazole-pyrimidine derivatives: synthesis and anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.19 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27323 | — | — | 1 | 6.55 |
| CHEMBL3397662 | — | — | 1 | 5.99 |
| CHEMBL3397658 | — | — | 1 | 5.70 |
| CHEMBL284328 | HOMIDIUM BROMIDE | 2.0 | 1 | 5.68 |
| CHEMBL3397661 | — | — | 1 | 4.91 |
| CHEMBL3397665 | — | — | 1 | 4.82 |
| CHEMBL3397664 | — | — | 1 | 4.72 |
| CHEMBL3397660 | — | — | 1 | 4.31 |
| CHEMBL3397659 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27323 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL3397662 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL3397658 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL284328 | HOMIDIUM BROMIDE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3397661 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL3397665 | — | IC50 | = | 15170.0 | nM | 4.82 |
| CHEMBL3397664 | — | IC50 | = | 18990.0 | nM | 4.72 |
| CHEMBL3397660 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL3397659 | — | IC50 | = | 87000.0 | nM | 4.06 |