Assay Detail
Binding
CHEMBL3404066
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of microtubule depolymerization in rat A10 cells after 18 hrs by indirect immunofluorescence assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | A10 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.52 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.01 |
| CHEMBL3403517 | — | — | 1 | 7.68 |
| CHEMBL3297898 | — | — | 1 | 6.99 |
| CHEMBL3403519 | — | — | 1 | 6.74 |
| CHEMBL3403513 | — | — | 1 | 6.22 |
| CHEMBL3403510 | — | — | 1 | 5.57 |
| CHEMBL3403509 | — | — | 1 | 5.52 |
| CHEMBL3403514 | — | — | 1 | 5.42 |
| CHEMBL3403512 | — | — | 1 | - |
| CHEMBL3403511 | — | — | 1 | - |
| CHEMBL3403515 | — | — | 1 | - |
| CHEMBL3403516 | — | — | 1 | - |
| CHEMBL3403518 | — | — | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL3403517 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3297898 | — | EC50 | = | 103.0 | nM | 6.99 |
| CHEMBL3403519 | — | EC50 | = | 182.0 | nM | 6.74 |
| CHEMBL3403513 | — | EC50 | = | 606.0 | nM | 6.22 |
| CHEMBL3403510 | — | EC50 | = | 2719.0 | nM | 5.57 |
| CHEMBL3403509 | — | EC50 | = | 2994.0 | nM | 5.52 |
| CHEMBL3403514 | — | EC50 | = | 3786.0 | nM | 5.42 |
| CHEMBL3403512 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3403511 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3403515 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3403516 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL3403518 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL428647 | PACLITAXEL | EC50 | - | — | - |