Assay Detail
Binding
CHEMBL3404161
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta (unknown origin) by biochemical Alphascreen assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and SAR study of potent and selective PI3Kδ inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.55 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2216892 | — | — | 1 | 9.70 |
| CHEMBL3403669 | — | — | 1 | 9.40 |
| CHEMBL3403670 | — | — | 1 | 9.22 |
| CHEMBL3403664 | — | — | 1 | 9.15 |
| CHEMBL3403665 | — | — | 1 | 8.92 |
| CHEMBL3403676 | — | — | 1 | 8.92 |
| CHEMBL3403668 | — | — | 1 | 8.89 |
| CHEMBL3403674 | — | — | 1 | 8.85 |
| CHEMBL3403671 | — | — | 1 | 8.77 |
| CHEMBL3403678 | — | — | 1 | 8.62 |
| CHEMBL3403667 | — | — | 1 | 8.60 |
| CHEMBL3403673 | — | — | 1 | 8.40 |
| CHEMBL3403677 | — | — | 1 | 8.08 |
| CHEMBL3403672 | — | — | 1 | 8.06 |
| CHEMBL3403679 | — | — | 1 | 7.82 |
| CHEMBL3400185 | — | — | 1 | 7.80 |
| CHEMBL3403666 | — | — | 1 | 7.80 |
| CHEMBL3403675 | — | — | 1 | 7.75 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 7.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2216892 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3403669 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3403670 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3403664 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL3403665 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3403676 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3403668 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3403674 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3403671 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3403678 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3403667 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3403673 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3403677 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL3403672 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL3403679 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3400185 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3403666 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3403675 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 24.0 | nM | 7.62 |