Assay Detail
Binding
CHEMBL3404182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-8-OH-DPAT from human 5-HT7 receptor expressed in CHOK1 cells after 30 mins by liquid scintillation counting analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.06 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282199 | — | — | 1 | 9.15 |
| CHEMBL350221 | OXITRIPTAN | 3.0 | 1 | 8.67 |
| CHEMBL3401493 | — | — | 1 | 8.52 |
| CHEMBL3401488 | — | — | 1 | 8.16 |
| CHEMBL3401482 | — | — | 1 | 7.92 |
| CHEMBL3401487 | — | — | 1 | 7.89 |
| CHEMBL3401479 | — | — | 1 | 7.67 |
| CHEMBL3401473 | — | — | 1 | 7.52 |
| CHEMBL3401486 | — | — | 1 | 7.45 |
| CHEMBL3401476 | — | — | 1 | 7.17 |
| CHEMBL3401491 | — | — | 1 | 7.05 |
| CHEMBL3401483 | — | — | 1 | 7.00 |
| CHEMBL3401478 | — | — | 1 | 6.84 |
| CHEMBL3401489 | — | — | 1 | 6.84 |
| CHEMBL3401474 | — | — | 1 | 6.83 |
| CHEMBL3401469 | — | — | 1 | 6.78 |
| CHEMBL3401475 | — | — | 1 | 6.73 |
| CHEMBL3401492 | — | — | 1 | 6.67 |
| CHEMBL3401481 | — | — | 1 | 6.64 |
| CHEMBL3401484 | — | — | 1 | 6.51 |
| CHEMBL3401470 | — | — | 1 | 6.45 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 6.41 |
| CHEMBL574827 | — | — | 1 | 6.30 |
| CHEMBL3401485 | — | — | 1 | 5.97 |
| CHEMBL3401480 | — | — | 1 | 5.95 |
| CHEMBL3401477 | — | — | 1 | 5.83 |
| CHEMBL3401490 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282199 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL350221 | OXITRIPTAN | Ki | = | 2.12 | nM | 8.67 |
| CHEMBL3401493 | — | Ki | = | 2.99 | nM | 8.52 |
| CHEMBL3401488 | — | Ki | = | 6.88 | nM | 8.16 |
| CHEMBL3401482 | — | Ki | = | 11.9 | nM | 7.92 |
| CHEMBL3401487 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL3401479 | — | Ki | = | 21.2 | nM | 7.67 |
| CHEMBL3401473 | — | Ki | = | 30.1 | nM | 7.52 |
| CHEMBL3401486 | — | Ki | = | 35.8 | nM | 7.45 |
| CHEMBL3401476 | — | Ki | = | 68.4 | nM | 7.17 |
| CHEMBL3401491 | — | Ki | = | 88.5 | nM | 7.05 |
| CHEMBL3401483 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL3401478 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL3401489 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL3401474 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL3401469 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL3401475 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL3401492 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL3401481 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL3401484 | — | Ki | = | 307.0 | nM | 6.51 |
| CHEMBL3401470 | — | Ki | = | 357.0 | nM | 6.45 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 388.0 | nM | 6.41 |
| CHEMBL574827 | — | Ki | = | 502.0 | nM | 6.30 |
| CHEMBL3401485 | — | Ki | = | 1082.0 | nM | 5.97 |
| CHEMBL3401480 | — | Ki | = | 1135.0 | nM | 5.95 |
| CHEMBL3401477 | — | Ki | = | 1464.0 | nM | 5.83 |
| CHEMBL3401490 | — | Ki | = | 1650.0 | nM | 5.78 |