Assay Detail
Binding
CHEMBL3404208
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Binding affinity to HIV-1 RRE RNA by fluorescence anisotropy
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Nucleobase modified neamines with a lysine as a linker, their inhibition specificity for TAR-Tat derived from HIV-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 5.91 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3401891 | — | — | 1 | 6.28 |
| CHEMBL3401892 | — | — | 1 | 6.24 |
| CHEMBL3401889 | — | — | 1 | 6.24 |
| CHEMBL3401890 | — | — | 1 | 6.19 |
| CHEMBL427409 | NEAMINE | — | 1 | 5.27 |
| CHEMBL3401888 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3401891 | — | Kd | = | 530.0 | nM | 6.28 |
| CHEMBL3401892 | — | Kd | = | 570.0 | nM | 6.24 |
| CHEMBL3401889 | — | Kd | = | 570.0 | nM | 6.24 |
| CHEMBL3401890 | — | Kd | = | 640.0 | nM | 6.19 |
| CHEMBL427409 | NEAMINE | Kd | = | 5400.0 | nM | 5.27 |
| CHEMBL3401888 | — | Kd | = | 5700.0 | nM | 5.24 |