Assay Detail
Binding
CHEMBL3404291
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain tubulin assembly
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.86 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.00 |
| CHEMBL3403517 | — | — | 1 | 5.96 |
| CHEMBL3297898 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3403517 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3297898 | — | IC50 | = | 2400.0 | nM | 5.62 |