Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3404384

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat hormone sensitive lipase assessed as oleic acid release from [3H]triolein by scintillation counting
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Hormone-sensitive lipase (CHEMBL5582)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Rat hormone sensitive lipase inhibition by cyclipostins and their analogs.
Vasilieva E, Dutta S, Malla RK, Martin BP, Spilling CD, Dupureur CM.
Bioorg Med Chem (2015) 23 : 944 -952
PubMed 25678014 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.72 7.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3401162 1 7.60
CHEMBL3401168 1 7.22
CHEMBL3401161 1 7.12
CHEMBL3401167 1 6.44
CHEMBL3401163 1 6.38
CHEMBL3401164 1 6.35
CHEMBL3401165 1 6.33
CHEMBL3401160 1 6.05
CHEMBL3401166 1 5.16
CHEMBL3401171 1 5.00
CHEMBL3401170 1 4.87
CHEMBL3401172 1 4.57
CHEMBL2179369 1 4.46
CHEMBL2179367 1 4.22
CHEMBL590031 1 4.00
CHEMBL603622 CYCLOPHOSTIN 1 -
CHEMBL3401159 1 -
CHEMBL3401169 1 -
CHEMBL2179365 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3401162 IC50 = 25.0 nM 7.60
CHEMBL3401168 IC50 = 60.0 nM 7.22
CHEMBL3401161 IC50 = 75.0 nM 7.12
CHEMBL3401167 IC50 = 360.0 nM 6.44
CHEMBL3401163 IC50 = 420.0 nM 6.38
CHEMBL3401164 IC50 = 450.0 nM 6.35
CHEMBL3401165 IC50 = 470.0 nM 6.33
CHEMBL3401160 IC50 = 900.0 nM 6.05
CHEMBL3401166 IC50 = 6900.0 nM 5.16
CHEMBL3401171 IC50 = 10000.0 nM 5.00
CHEMBL3401170 IC50 = 13500.0 nM 4.87
CHEMBL3401172 IC50 = 27000.0 nM 4.57
CHEMBL2179369 IC50 = 35000.0 nM 4.46
CHEMBL2179367 IC50 = 60000.0 nM 4.22
CHEMBL590031 IC50 = 100000.0 nM 4.00
CHEMBL603622 CYCLOPHOSTIN IC50 > 100000.0 nM -
CHEMBL3401159 IC50 > 100000.0 nM -
CHEMBL3401169 IC50 > 100000.0 nM -
CHEMBL2179365 IC50 > 100000.0 nM -