Assay Detail
Binding
CHEMBL3404560
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MAOA using kynuramine substrate assessed as reduction in MAO-generated 4-hydroxyquinoline level by fluorescence spectrophotometry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The synthesis and evaluation of sesamol and benzodioxane derivatives as inhibitors of monoamine oxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.64 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191083 | METHYLENE BLUE CATION | 4.0 | 1 | 7.16 |
| CHEMBL3402196 | — | — | 1 | 4.88 |
| CHEMBL3402197 | — | — | 1 | 4.77 |
| CHEMBL3402198 | — | — | 1 | 4.56 |
| CHEMBL3402195 | — | — | 1 | 4.44 |
| CHEMBL3402190 | — | — | 1 | 4.42 |
| CHEMBL3402189 | — | — | 1 | 4.29 |
| CHEMBL3402200 | — | — | 1 | 4.16 |
| CHEMBL3402199 | — | — | 1 | 4.15 |
| CHEMBL3400170 | — | — | 1 | 4.11 |
| CHEMBL3402191 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191083 | METHYLENE BLUE CATION | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3402196 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL3402197 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL3402198 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL3402195 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL3402190 | — | IC50 | = | 38400.0 | nM | 4.42 |
| CHEMBL3402189 | — | IC50 | = | 51800.0 | nM | 4.29 |
| CHEMBL3402200 | — | IC50 | = | 69400.0 | nM | 4.16 |
| CHEMBL3402199 | — | IC50 | = | 70400.0 | nM | 4.15 |
| CHEMBL3400170 | — | IC50 | = | 77100.0 | nM | 4.11 |
| CHEMBL3402191 | — | IC50 | = | 87700.0 | nM | 4.06 |