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Assay Detail

CHEMBL3404567

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Competitive inhibition of human recombinant MAOB using kynuramine substrate assessed as reduction in MAO-generated 4-hydroxyquinoline level by Lineweaver-Burk plot
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The synthesis and evaluation of sesamol and benzodioxane derivatives as inhibitors of monoamine oxidase.
Engelbrecht I, Petzer JP, Petzer A.
Bioorg Med Chem Lett (2015) 25 : 1896 -1900
PubMed 25857942 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.39 7.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3402197 1 7.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3402197 Ki = 41.0 nM 7.39