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Assay Detail

CHEMBL3404575

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mouse IL5-mediated mouse Y16 cell proliferation after 48 hrs by WST1 assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Cell Type Y16
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Interleukin-5 (CHEMBL1163111)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Exploration of benzamidochromenone derivatives with conformational restrictor as interleukin-5 inhibitors.
Venkateswararao E, Manickam M, Boggu P, Kim Y, Jung SH.
Bioorg Med Chem (2015) 23 : 2498 -2504
PubMed 25865130 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.82 5.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3402258 1 5.21
CHEMBL3403299 1 5.00
CHEMBL486626 SOPHORICOSIDE 1 4.97
CHEMBL2316358 1 4.90
CHEMBL3402261 1 4.80
CHEMBL3403297 1 4.75
CHEMBL3402259 1 4.72
CHEMBL3403294 1 4.72
CHEMBL3403293 1 4.70
CHEMBL3403300 1 4.66
CHEMBL1370 BUDESONIDE 4.0 1 4.58
CHEMBL3403295 1 -
CHEMBL3403296 1 -
CHEMBL3403298 1 -
CHEMBL3403301 1 -
CHEMBL3403302 1 -
CHEMBL3403303 1 -
CHEMBL3403304 1 -
CHEMBL3402262 1 -
CHEMBL3402260 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3402258 IC50 = 6100.0 nM 5.21
CHEMBL3403299 IC50 = 10000.0 nM 5.00
CHEMBL486626 SOPHORICOSIDE IC50 = 10600.0 nM 4.97
CHEMBL2316358 IC50 = 12600.0 nM 4.90
CHEMBL3402261 IC50 = 16000.0 nM 4.80
CHEMBL3403297 IC50 = 18000.0 nM 4.75
CHEMBL3402259 IC50 = 19000.0 nM 4.72
CHEMBL3403294 IC50 = 19200.0 nM 4.72
CHEMBL3403293 IC50 = 20000.0 nM 4.70
CHEMBL3403300 IC50 = 22000.0 nM 4.66
CHEMBL1370 BUDESONIDE IC50 = 26200.0 nM 4.58
CHEMBL3403295 IC50 > 30000.0 nM -
CHEMBL3403296 IC50 > 30000.0 nM -
CHEMBL3403298 IC50 > 30000.0 nM -
CHEMBL3403301 IC50 > 30000.0 nM -
CHEMBL3403302 IC50 > 30000.0 nM -
CHEMBL3403303 IC50 > 30000.0 nM -
CHEMBL3403304 IC50 > 30000.0 nM -
CHEMBL3402262 IC50 > 30000.0 nM -
CHEMBL3402260 IC50 > 30000.0 nM -