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Assay Detail

CHEMBL3404593

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine carbonic anhydrase 2 assessed as hydrolysis of p-nitrophenyl acetate after 30 mins by spectrophotometric method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 2 (CHEMBL2283)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Diarylsulfonamides and their bioisosteres as dual inhibitors of alkaline phosphatase and carbonic anhydrase: Structure activity relationship and molecular modelling studies.
Al-Rashida M, Ejaz SA, Ali S, Shaukat A, Hamayoun M, Ahmed M, Iqbal J.
Bioorg Med Chem (2015) 23 : 2435 -2444
PubMed 25865133 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 6.65 7.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3403326 1 7.46
CHEMBL3403323 1 7.24
CHEMBL23922 1 7.00
CHEMBL3403327 1 7.00
CHEMBL3403324 1 6.87
CHEMBL3403325 1 6.82
CHEMBL511186 1 6.67
CHEMBL1607835 1 6.62
CHEMBL3403318 1 6.26
CHEMBL3403321 1 6.18
CHEMBL3403317 1 6.16
CHEMBL3403320 1 6.09
CHEMBL20 ACETAZOLAMIDE 4.0 1 6.02
CHEMBL3403328 1 -
CHEMBL3403329 1 -
CHEMBL182659 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3403326 IC50 = 35.0 nM 7.46
CHEMBL3403323 IC50 = 57.0 nM 7.24
CHEMBL23922 IC50 = 100.0 nM 7.00
CHEMBL3403327 IC50 = 100.0 nM 7.00
CHEMBL3403324 IC50 = 134.0 nM 6.87
CHEMBL3403325 IC50 = 152.0 nM 6.82
CHEMBL511186 IC50 = 215.0 nM 6.67
CHEMBL1607835 IC50 = 241.0 nM 6.62
CHEMBL3403318 IC50 = 544.0 nM 6.26
CHEMBL3403321 IC50 = 656.0 nM 6.18
CHEMBL3403317 IC50 = 691.0 nM 6.16
CHEMBL3403320 IC50 = 821.0 nM 6.09
CHEMBL20 ACETAZOLAMIDE IC50 = 960.0 nM 6.02
CHEMBL3403328 IC50 - -
CHEMBL3403329 IC50 - -
CHEMBL182659 IC50 - -