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Assay Detail

CHEMBL3404600

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-ketanserin from human cloned 5-HT2A receptor expressed in CHO-K1 cells using seven compounds concentrations
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO-K1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 2A (CHEMBL224)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Fingerprint-based consensus virtual screening towards structurally new 5-HT(6)R ligands.
Smusz S, Kurczab R, Satała G, Bojarski AJ.
Bioorg Med Chem Lett (2015) 25 : 1827 -1830
PubMed 25866241 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 5.67 6.53

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1580288 1 6.53
CHEMBL2011865 1 4.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1580288 Ki = 296.0 nM 6.53
CHEMBL2011865 Ki = 15830.0 nM 4.80