Assay Detail
Functional
CHEMBL3404612
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Inhibition of IL2 production in activated mouse lymphocytes after 3 hrs by ELISA
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Lymphocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2-(Isopropylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as selective phosphodiesterase 7 inhibitors with potent in vivo efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.23 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3403346 | — | — | 1 | 6.82 |
| CHEMBL3403373 | — | — | 1 | 6.57 |
| CHEMBL3403372 | — | — | 1 | 6.54 |
| CHEMBL3403371 | — | — | 1 | 6.12 |
| CHEMBL3403367 | — | — | 1 | 6.12 |
| CHEMBL3403370 | — | — | 1 | 5.75 |
| CHEMBL3403366 | — | — | 1 | 5.70 |
| CHEMBL3403369 | — | — | 1 | - |
| CHEMBL3403368 | — | — | 1 | - |
| CHEMBL3403365 | — | — | 1 | - |
| CHEMBL3403364 | — | — | 1 | - |
| CHEMBL3403363 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3403346 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3403373 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3403372 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3403371 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL3403367 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL3403370 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3403366 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3403369 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL3403368 | — | IC50 | - | — | - | |
| CHEMBL3403365 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL3403364 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL3403363 | — | IC50 | - | — | - |