Assay Detail
Binding
CHEMBL3404716
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Displacement of [125I]IL-8 from human recombinant CXCR2 receptor expressed in HEK293 cells by scintillation counting analysis
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and evaluation of a novel monocyclic series of CXCR2 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.43 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446458 | — | — | 1 | 9.00 |
| CHEMBL3403851 | — | — | 1 | 8.60 |
| CHEMBL397237 | — | — | 1 | 8.40 |
| CHEMBL3403854 | — | — | 1 | 8.40 |
| CHEMBL3403850 | — | — | 1 | 8.40 |
| CHEMBL3403855 | — | — | 1 | 8.30 |
| CHEMBL3403848 | — | — | 1 | 8.30 |
| CHEMBL3403849 | — | — | 1 | 8.10 |
| CHEMBL3403852 | — | — | 1 | 8.10 |
| CHEMBL3403853 | — | — | 1 | 8.10 |
| CHEMBL3403840 | — | — | 1 | 8.00 |
| CHEMBL3403835 | — | — | 1 | 7.90 |
| CHEMBL3403847 | — | — | 1 | 7.90 |
| CHEMBL3403843 | — | — | 1 | 7.60 |
| CHEMBL3403846 | — | — | 1 | 7.50 |
| CHEMBL3403842 | — | — | 1 | 7.50 |
| CHEMBL3403834 | — | — | 1 | 7.50 |
| CHEMBL3403839 | — | — | 1 | 7.30 |
| CHEMBL3403845 | — | — | 1 | 7.20 |
| CHEMBL3403841 | — | — | 1 | 7.10 |
| CHEMBL3403830 | — | — | 1 | 7.10 |
| CHEMBL3403838 | — | — | 1 | 6.80 |
| CHEMBL3403836 | — | — | 1 | 6.80 |
| CHEMBL3403833 | — | — | 1 | 6.40 |
| CHEMBL3403828 | — | — | 1 | 6.40 |
| CHEMBL3403837 | — | — | 1 | 6.20 |
| CHEMBL3403829 | — | — | 1 | 6.10 |
| CHEMBL3403832 | — | — | 1 | 5.50 |
| CHEMBL3403831 | — | — | 1 | 5.10 |
| CHEMBL3403844 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446458 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3403851 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL397237 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL3403854 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL3403850 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL3403855 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3403848 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3403849 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL3403852 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL3403853 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL3403840 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3403835 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL3403847 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL3403843 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL3403846 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL3403842 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL3403834 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL3403839 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL3403845 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL3403841 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL3403830 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL3403838 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL3403836 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL3403833 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL3403828 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL3403837 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL3403829 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL3403832 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL3403831 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL3403844 | — | IC50 | > | 10000.0 | nM | - |