Assay Detail
Functional
CHEMBL3404799
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human S1P1 receptor assessed as change in cAMP level by homogeneous time resolved fluorescence cyclase assay
37
Total Activities
32
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 35 | 8.50 | 10.52 |
| IC50 | 2 | 10.32 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3403631 | — | — | 3 | 11.00 |
| CHEMBL3403619 | — | — | 2 | 10.52 |
| CHEMBL3403632 | — | — | 1 | 10.40 |
| CHEMBL3403630 | — | — | 1 | 10.40 |
| CHEMBL3400909 | — | — | 1 | 10.40 |
| CHEMBL3400910 | — | — | 1 | 10.40 |
| CHEMBL3403626 | — | — | 1 | 9.85 |
| CHEMBL3403636 | — | — | 1 | 9.82 |
| CHEMBL3400916 | — | — | 1 | 9.52 |
| CHEMBL3403622 | — | — | 1 | 9.39 |
| CHEMBL3403629 | — | — | 1 | 9.32 |
| CHEMBL3403634 | — | — | 1 | 9.17 |
| CHEMBL3403620 | — | — | 2 | 8.92 |
| CHEMBL3403621 | — | — | 2 | 8.85 |
| CHEMBL3403628 | — | — | 1 | 8.77 |
| CHEMBL3403635 | — | — | 1 | 8.77 |
| CHEMBL3403633 | — | — | 1 | 8.68 |
| CHEMBL3400906 | — | — | 1 | 8.64 |
| CHEMBL3403623 | — | — | 1 | 8.48 |
| CHEMBL3403625 | — | — | 1 | 8.17 |
| CHEMBL3403627 | — | — | 1 | 7.96 |
| CHEMBL3400911 | — | — | 1 | 7.72 |
| CHEMBL3400908 | — | — | 1 | 7.66 |
| CHEMBL3400907 | — | — | 1 | 7.60 |
| CHEMBL3403617 | — | — | 1 | 6.82 |
| CHEMBL3403624 | — | — | 1 | 6.77 |
| CHEMBL3403618 | — | — | 1 | 6.77 |
| CHEMBL3400913 | — | — | 1 | 6.66 |
| CHEMBL3400914 | — | — | 1 | 6.54 |
| CHEMBL3400917 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3403631 | — | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL3403619 | — | EC50 | = | 0.03 | nM | 10.52 |
| CHEMBL3400910 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL3400909 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL3403630 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL3403631 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL3403632 | — | EC50 | = | 0.04 | nM | 10.40 |
| CHEMBL3403619 | — | EC50 | = | 0.06 | nM | 10.22 |
| CHEMBL3403626 | — | EC50 | = | 0.14 | nM | 9.85 |
| CHEMBL3403636 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL3403631 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL3400916 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3403622 | — | EC50 | = | 0.41 | nM | 9.39 |
| CHEMBL3403629 | — | EC50 | = | 0.48 | nM | 9.32 |
| CHEMBL3403634 | — | EC50 | = | 0.67 | nM | 9.17 |
| CHEMBL3403620 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3403621 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3403628 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3403635 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3403621 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3403633 | — | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3403620 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3400906 | — | EC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3403623 | — | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3403625 | — | EC50 | = | 6.8 | nM | 8.17 |
| CHEMBL3403627 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3400911 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3400908 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3400907 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3403617 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3403618 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3403624 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3400913 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3400914 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3400917 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3400915 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3400912 | — | EC50 | = | 10000.0 | nM | 5.00 |