Assay Detail
Binding
CHEMBL3404822
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Inhibition of human recombinant soluble MAO-B assessed as thermal shift after 20 mins by SYPRO orange staining-based fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.84 | 5.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279390 | LAZABEMIDE | 2.0 | 1 | 5.15 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 4.82 |
| CHEMBL338404 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279390 | LAZABEMIDE | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL396778 | SAFINAMIDE | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL338404 | — | EC50 | = | 29000.0 | nM | 4.54 |