Assay Detail
Functional
CHEMBL3405049
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of degranulation in human LAD2 cells assessed as inhibition of IgE-induced beta-hexosaminidase release preincubated for 30 mins by p-nitrophenyl-N-acetyl-D-glucosamide-based spectrophotometric assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LAD2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 7-azaindole derivatives as potent Orai inhibitors showing efficacy in a preclinical model of asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.33 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3403744 | — | — | 1 | 6.43 |
| CHEMBL3403751 | — | — | 1 | 6.35 |
| CHEMBL3403753 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3403744 | — | IC50 | = | 372.0 | nM | 6.43 |
| CHEMBL3403751 | — | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL3403753 | — | IC50 | = | 630.0 | nM | 6.20 |