Assay Detail
Functional
CHEMBL3405050
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IL2 secretion in rat whole blood after 24 hrs by Rat IL-2 DuoSet assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 7-azaindole derivatives as potent Orai inhibitors showing efficacy in a preclinical model of asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.11 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3403744 | — | — | 1 | 6.30 |
| CHEMBL3403753 | — | — | 1 | 6.13 |
| CHEMBL3403751 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3403744 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3403753 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL3403751 | — | IC50 | = | 1300.0 | nM | 5.89 |