Assay Detail
Functional
CHEMBL3405272
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Influenza A virus A/PR/8/34 strain incubated with MDCK cells assessed as cell protection after 72 hrs by phenotypic cell protection assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.37 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3401981 | — | — | 1 | 9.00 |
| CHEMBL3318007 | PIMODIVIR | 3.0 | 1 | 8.70 |
| CHEMBL3401983 | — | — | 1 | 8.22 |
| CHEMBL3401986 | — | — | 1 | 7.85 |
| CHEMBL3401980 | — | — | 1 | 7.72 |
| CHEMBL3401975 | — | — | 1 | 7.60 |
| CHEMBL3401978 | — | — | 1 | 7.32 |
| CHEMBL3401984 | — | — | 1 | 7.17 |
| CHEMBL3401979 | — | — | 1 | 7.14 |
| CHEMBL3401976 | — | — | 1 | 7.04 |
| CHEMBL3401989 | — | — | 1 | 6.89 |
| CHEMBL3401985 | — | — | 1 | 6.80 |
| CHEMBL3401977 | — | — | 1 | 6.70 |
| CHEMBL3401988 | — | — | 1 | 6.68 |
| CHEMBL3401990 | — | — | 1 | 6.64 |
| CHEMBL3401987 | — | — | 1 | 6.51 |
| CHEMBL3401982 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3401981 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3318007 | PIMODIVIR | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3401983 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3401986 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3401980 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3401975 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3401978 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3401984 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3401979 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL3401976 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3401989 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3401985 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3401977 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3401988 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3401990 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3401987 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL3401982 | — | IC50 | - | — | - |