Assay Detail
Binding
CHEMBL3405277
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Inhibition of FLT3 (unknown origin)
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.08 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3401987 | — | — | 1 | 6.82 |
| CHEMBL3401984 | — | — | 1 | 6.80 |
| CHEMBL3401978 | — | — | 1 | 6.68 |
| CHEMBL3401979 | — | — | 1 | 6.10 |
| CHEMBL3401990 | — | — | 1 | 6.08 |
| CHEMBL3401988 | — | — | 1 | 6.01 |
| CHEMBL3401976 | — | — | 1 | 5.96 |
| CHEMBL3401983 | — | — | 1 | 5.92 |
| CHEMBL3401986 | — | — | 1 | 5.85 |
| CHEMBL3401989 | — | — | 1 | 5.75 |
| CHEMBL3401980 | — | — | 1 | 5.55 |
| CHEMBL3401985 | — | — | 1 | 5.40 |
| CHEMBL3401982 | — | — | 1 | - |
| CHEMBL3318007 | PIMODIVIR | 3.0 | 1 | - |
| CHEMBL3401981 | — | — | 1 | - |
| CHEMBL3401977 | — | — | 1 | - |
| CHEMBL3401975 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3401987 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL3401984 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL3401978 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL3401979 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL3401990 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL3401988 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL3401976 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL3401983 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL3401986 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3401989 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL3401980 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL3401985 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL3401982 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL3318007 | PIMODIVIR | Ki | > | 4000.0 | nM | - |
| CHEMBL3401981 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL3401977 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL3401975 | — | Ki | > | 4000.0 | nM | - |