Assay Detail
Binding
CHEMBL3405596
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Inhibition of Streptococcus mutans OMZ65 sortase A lacking N-terminal membrane anchor domain (1 to 40 amino acids) expressed in Escherichia coli TOP10 using Dabcyl-QALPETGEE-Edans substrate incubated for 1 hr by fluorescence spectrophotometry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Streptococcus mutans |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Streptococcus mutans sortase A inhibitory metabolites from the flowers of Sophora japonica.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.15 | 4.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3400189 | — | — | 1 | 4.23 |
| CHEMBL498879 | NICOTIFLOROSIDE | — | 1 | 4.22 |
| CHEMBL258394 | NARCISSIN | — | 1 | 4.21 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.04 |
| CHEMBL3403974 | — | — | 1 | 4.03 |
| CHEMBL78771 | Para-Hydroxymercuribenzoic acid | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3400189 | — | IC50 | = | 58600.0 | nM | 4.23 |
| CHEMBL498879 | NICOTIFLOROSIDE | IC50 | = | 60700.0 | nM | 4.22 |
| CHEMBL258394 | NARCISSIN | IC50 | = | 62100.0 | nM | 4.21 |
| CHEMBL140 | CURCUMIN | IC50 | = | 91500.0 | nM | 4.04 |
| CHEMBL3403974 | — | IC50 | = | 94300.0 | nM | 4.03 |
| CHEMBL78771 | Para-Hydroxymercuribenzoic acid | IC50 | = | 112500.0 | nM | - |