Assay Detail
Binding
CHEMBL3405830
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at histamine H1 receptor in guinea pig jejunum assessed as reduction in histamine-induced contractions
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Jejunum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Loratadine analogues as MAGL inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.32 | 8.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511 | PYRILAMINE | 4.0 | 1 | 8.84 |
| CHEMBL998 | LORATADINE | 4.0 | 1 | 7.14 |
| CHEMBL3401455 | — | — | 1 | 6.81 |
| CHEMBL3402827 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511 | PYRILAMINE | Kd | = | 1.445 | nM | 8.84 |
| CHEMBL998 | LORATADINE | Kd | = | 72.44 | nM | 7.14 |
| CHEMBL3401455 | — | Kd | = | 154.88 | nM | 6.81 |
| CHEMBL3402827 | — | Kd | = | 316.23 | nM | 6.50 |