Assay Detail
Binding
CHEMBL3406098
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Inhibition of PI3K (unknown origin) by TR-FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.88 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3400288 | — | — | 1 | 7.00 |
| CHEMBL3400291 | — | — | 1 | 6.76 |
| CHEMBL3400290 | — | — | 1 | - |
| CHEMBL3400289 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3400288 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3400291 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL3400290 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL3400289 | — | IC50 | > | 1000.0 | nM | - |