Assay Detail
Binding
CHEMBL3406126
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kgamma (unknown origin)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 5.98 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3401977 | — | — | 1 | 6.40 |
| CHEMBL3401978 | — | — | 1 | 6.20 |
| CHEMBL3401981 | — | — | 1 | 6.16 |
| CHEMBL3401984 | — | — | 1 | 6.15 |
| CHEMBL3401979 | — | — | 1 | 6.12 |
| CHEMBL3401987 | — | — | 1 | 6.11 |
| CHEMBL3401983 | — | — | 1 | 5.96 |
| CHEMBL3401990 | — | — | 1 | 5.92 |
| CHEMBL3401988 | — | — | 1 | 5.85 |
| CHEMBL3401980 | — | — | 1 | 5.82 |
| CHEMBL3401989 | — | — | 1 | 5.55 |
| CHEMBL3401975 | — | — | 1 | 5.54 |
| CHEMBL3401976 | — | — | 1 | - |
| CHEMBL3401982 | — | — | 1 | - |
| CHEMBL3401985 | — | — | 1 | - |
| CHEMBL3401986 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3401977 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL3401978 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL3401981 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL3401984 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL3401979 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL3401987 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL3401983 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL3401990 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL3401988 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3401980 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL3401989 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL3401975 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL3401976 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL3401982 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL3401985 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL3401986 | — | Ki | > | 4000.0 | nM | - |