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Assay Detail

CHEMBL3406146

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf9 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Sf9
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Cyclin-dependent kinase 2/cyclin E1 (CHEMBL1907605)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Novel arylazopyrazole inhibitors of cyclin-dependent kinases.
Jorda R, Schütznerová E, Cankař P, Brychtová V, Navrátilová J, Kryštof V.
Bioorg Med Chem (2015) 23 : 1975 -1981
PubMed 25835357 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 4.95 6.26

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3402056 1 6.26
CHEMBL3402061 1 4.82
CHEMBL3402060 1 4.78
CHEMBL3402057 1 4.76
CHEMBL215205 1 4.70
CHEMBL3402063 1 4.37
CHEMBL3402064 1 -
CHEMBL3402062 1 -
CHEMBL3402059 1 -
CHEMBL3402058 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3402056 IC50 = 550.0 nM 6.26
CHEMBL3402061 IC50 = 15000.0 nM 4.82
CHEMBL3402060 IC50 = 16800.0 nM 4.78
CHEMBL3402057 IC50 = 17400.0 nM 4.76
CHEMBL215205 IC50 = 20000.0 nM 4.70
CHEMBL3402063 IC50 = 42800.0 nM 4.37
CHEMBL3402064 IC50 > 50000.0 nM -
CHEMBL3402062 IC50 > 25000.0 nM -
CHEMBL3402059 IC50 > 50000.0 nM -
CHEMBL3402058 IC50 > 100000.0 nM -