Assay Detail
Functional
CHEMBL3406147
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Cytotoxicity against human K562 cells after 72 hrs by calcein AM staining-based fluorescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel arylazopyrazole inhibitors of cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.30 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3402056 | — | — | 1 | 4.77 |
| CHEMBL215205 | — | — | 1 | 4.48 |
| CHEMBL3402058 | — | — | 1 | 4.20 |
| CHEMBL3402063 | — | — | 1 | 4.19 |
| CHEMBL3402060 | — | — | 1 | 4.17 |
| CHEMBL3402059 | — | — | 1 | 4.01 |
| CHEMBL3402064 | — | — | 1 | - |
| CHEMBL3402062 | — | — | 1 | - |
| CHEMBL3402061 | — | — | 1 | - |
| CHEMBL3402057 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3402056 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL215205 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL3402058 | — | IC50 | = | 62600.0 | nM | 4.20 |
| CHEMBL3402063 | — | IC50 | = | 64900.0 | nM | 4.19 |
| CHEMBL3402060 | — | IC50 | = | 67400.0 | nM | 4.17 |
| CHEMBL3402059 | — | IC50 | = | 98500.0 | nM | 4.01 |
| CHEMBL3402064 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3402062 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3402061 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3402057 | — | IC50 | > | 100000.0 | nM | - |