Assay Detail
Functional
CHEMBL3406687
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Relaxation effect on phenylephrine-induced contractile response in isolated rabbit corpus cavernosum
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Corpus cavernosum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
8-(3-chloro-4-methoxybenzyl)-8H-pyrido[2,3-d]pyrimidin-7-one derivatives as potent and selective phosphodiesterase 5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 8.47 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3404009 | — | — | 1 | 9.07 |
| CHEMBL3404010 | — | — | 1 | 8.66 |
| CHEMBL3404006 | — | — | 1 | 8.07 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.06 |
| CHEMBL3404016 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3404009 | — | EC50 | = | 0.85 | nM | 9.07 |
| CHEMBL3404010 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3404006 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL192 | SILDENAFIL | EC50 | = | 8.7 | nM | 8.06 |
| CHEMBL3404016 | — | EC50 | > | 100.0 | nM | - |