Assay Detail
Functional
CHEMBL3406962
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Photosensitizing activity against human HeLa cells assessed as reduction in cell viability pre-incubated for 24 hrs followed by 15 mins exposure to 670 to 710 nm light at dose of 2.0 J/cm2 and measured 12 hrs after radiation by WST-8 assay
20
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, optical properties and preliminary in vitro photodynamic effect of pyridyl and quinoxalyl substituted chlorins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.57 | 7.48 |
| Activity | 10 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3400531 | — | — | 2 | 7.48 |
| CHEMBL3400530 | — | — | 2 | 7.15 |
| CHEMBL3400524 | — | — | 2 | 6.85 |
| CHEMBL3400527 | — | — | 2 | 6.77 |
| CHEMBL504821 | METHYL PHEOPHORBIDE A | — | 2 | 6.74 |
| CHEMBL3400532 | — | — | 2 | 6.72 |
| CHEMBL3400525 | — | — | 2 | 6.24 |
| CHEMBL3400528 | — | — | 2 | 6.20 |
| CHEMBL3400529 | — | — | 2 | 6.00 |
| CHEMBL3400526 | — | — | 2 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3400531 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3400530 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3400524 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL3400527 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL504821 | METHYL PHEOPHORBIDE A | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL3400532 | — | IC50 | = | 189.0 | nM | 6.72 |
| CHEMBL3400525 | — | IC50 | = | 581.0 | nM | 6.24 |
| CHEMBL3400528 | — | IC50 | = | 631.0 | nM | 6.20 |
| CHEMBL3400529 | — | IC50 | = | 992.0 | nM | 6.00 |
| CHEMBL3400526 | — | IC50 | = | 3118.0 | nM | 5.51 |
| CHEMBL3400524 | — | Activity | - | — | - | |
| CHEMBL3400525 | — | Activity | - | — | - | |
| CHEMBL3400526 | — | Activity | - | — | - | |
| CHEMBL3400527 | — | Activity | - | — | - | |
| CHEMBL3400528 | — | Activity | - | — | - | |
| CHEMBL3400529 | — | Activity | - | — | - | |
| CHEMBL3400530 | — | Activity | - | — | - | |
| CHEMBL3400531 | — | Activity | - | — | - | |
| CHEMBL3400532 | — | Activity | - | — | - | |
| CHEMBL504821 | METHYL PHEOPHORBIDE A | Activity | - | — | - |