Assay Detail
Binding
CHEMBL3406977
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant rat soluble epoxide hydrolase assessed as increase in fluorescence intensity by fluorescence plate reader
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bifunctional epoxide hydrolase 2 (CHEMBL5669) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Three-dimensional rational approach to the discovery of potent substituted cyclopropyl urea soluble epoxide hydrolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.52 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3401636 | — | — | 1 | 9.70 |
| CHEMBL3401639 | — | — | 1 | 9.70 |
| CHEMBL3401638 | — | — | 1 | 9.10 |
| CHEMBL3401635 | — | — | 1 | 8.49 |
| CHEMBL3401634 | — | — | 1 | 8.41 |
| CHEMBL3401632 | — | — | 1 | 7.93 |
| CHEMBL3401637 | — | — | 1 | 7.56 |
| CHEMBL3401630 | — | — | 1 | 7.25 |
| CHEMBL3401631 | — | — | 1 | - |
| CHEMBL3401633 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3401636 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3401639 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3401638 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3401635 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3401634 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL3401632 | — | IC50 | = | 11.7 | nM | 7.93 |
| CHEMBL3401637 | — | IC50 | = | 27.7 | nM | 7.56 |
| CHEMBL3401630 | — | IC50 | = | 55.6 | nM | 7.25 |
| CHEMBL3401631 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL3401633 | — | IC50 | > | 100.0 | nM | - |