Assay Detail
Functional
CHEMBL3407029
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Antiproliferative activity against exponentially growing adherent human HCC1937 cells assessed as inhibition of cell proliferation after 72 hrs by luminescence detection based ATPlite assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC1937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and activities towards resistant cancer cells of sulfone and sulfoxide griseofulvin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.92 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3402426 | — | — | 1 | 6.40 |
| CHEMBL3402428 | — | — | 1 | 6.16 |
| CHEMBL3402427 | — | — | 1 | 6.05 |
| CHEMBL3402421 | — | — | 1 | 5.85 |
| CHEMBL3402423 | — | — | 1 | 5.80 |
| CHEMBL3402422 | — | — | 1 | 5.23 |
| CHEMBL3402424 | — | — | 1 | - |
| CHEMBL3402420 | — | — | 1 | - |
| CHEMBL491938 | — | — | 1 | - |
| CHEMBL3402425 | — | — | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | - |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | - |
| CHEMBL562 | GRISEOFULVIN | 4.0 | 1 | - |
| CHEMBL521969 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3402426 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3402428 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3402427 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL3402421 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3402423 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3402422 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3402424 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3402420 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL491938 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3402425 | — | IC50 | - | — | - | |
| CHEMBL428647 | PACLITAXEL | IC50 | > | 10000.0 | nM | - |
| CHEMBL94657 | PATUPILONE | IC50 | > | 10000.0 | nM | - |
| CHEMBL553025 | VINORELBINE | IC50 | > | 10000.0 | nM | - |
| CHEMBL562 | GRISEOFULVIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL521969 | — | IC50 | > | 10000.0 | nM | - |