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Assay Detail

CHEMBL3407102

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of butter milk Xanthine oxidase using xanthine as substrate preincubated for for 3 mins by spectrophotometry
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Not specified
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Design and synthesis of novel 2-(indol-5-yl)thiazole derivatives as xanthine oxidase inhibitors.
Song JU, Choi SP, Kim TH, Jung CK, Lee JY, Jung SH, Kim GT.
Bioorg Med Chem Lett (2015) 25 : 1254 -1258
PubMed 25704891 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 7.99 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3402699 1 8.52
CHEMBL1164729 FEBUXOSTAT 4.0 1 8.51
CHEMBL3402696 1 8.46
CHEMBL3402704 1 8.41
CHEMBL3402690 1 8.38
CHEMBL3402693 1 8.36
CHEMBL3402698 1 8.31
CHEMBL3402692 1 8.26
CHEMBL3402702 1 8.25
CHEMBL3402687 1 8.24
CHEMBL3402703 1 8.22
CHEMBL3402688 1 8.14
CHEMBL3402705 1 8.07
CHEMBL3402700 1 8.05
CHEMBL3402697 1 7.97
CHEMBL3402691 1 7.92
CHEMBL3402701 1 7.91
CHEMBL3402689 1 7.80
CHEMBL3402695 1 7.05
CHEMBL3400175 1 6.96
CHEMBL3402694 1 6.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3402699 IC50 = 3.0 nM 8.52
CHEMBL1164729 FEBUXOSTAT IC50 = 3.1 nM 8.51
CHEMBL3402696 IC50 = 3.5 nM 8.46
CHEMBL3402704 IC50 = 3.9 nM 8.41
CHEMBL3402690 IC50 = 4.2 nM 8.38
CHEMBL3402693 IC50 = 4.4 nM 8.36
CHEMBL3402698 IC50 = 4.9 nM 8.31
CHEMBL3402692 IC50 = 5.5 nM 8.26
CHEMBL3402702 IC50 = 5.6 nM 8.25
CHEMBL3402687 IC50 = 5.7 nM 8.24
CHEMBL3402703 IC50 = 6.0 nM 8.22
CHEMBL3402688 IC50 = 7.3 nM 8.14
CHEMBL3402705 IC50 = 8.6 nM 8.07
CHEMBL3402700 IC50 = 9.0 nM 8.05
CHEMBL3402697 IC50 = 10.7 nM 7.97
CHEMBL3402691 IC50 = 12.0 nM 7.92
CHEMBL3402701 IC50 = 12.3 nM 7.91
CHEMBL3402689 IC50 = 16.0 nM 7.80
CHEMBL3402695 IC50 = 90.0 nM 7.05
CHEMBL3400175 IC50 = 110.0 nM 6.96
CHEMBL3402694 IC50 = 895.0 nM 6.05