Assay Detail
Binding
CHEMBL3407119
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Inhibition of recombinant Porphyromonas gingivalis gamma-carbonic anhydrase by stopped flow CO2 hydrase assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Porphyromonas gingivalis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 6.17 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 6.88 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 6.80 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 6.77 |
| CHEMBL6784 | — | — | 1 | 6.75 |
| CHEMBL6724 | — | — | 1 | 6.70 |
| CHEMBL2324869 | — | — | 1 | 6.66 |
| CHEMBL6919 | — | — | 1 | 6.65 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 6.56 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.49 |
| CHEMBL224292 | — | — | 1 | 6.49 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.46 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | 4.0 | 1 | 6.42 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 6.38 |
| CHEMBL328560 | SULTHIAME | 3.0 | 1 | 6.37 |
| CHEMBL265674 | — | — | 1 | 6.29 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 6.25 |
| CHEMBL6753 | — | — | 1 | 6.22 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 6.21 |
| CHEMBL7092 | — | — | 1 | 6.18 |
| CHEMBL6853 | — | — | 1 | 6.17 |
| CHEMBL6633 | — | — | 1 | 6.16 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 6.16 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 6.15 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 6.14 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 6.13 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 6.12 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.05 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | 3.0 | 1 | 6.03 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 5.99 |
| CHEMBL266240 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77517 | INDISULAM | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL118 | CELECOXIB | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL6784 | — | Ki | = | 178.0 | nM | 6.75 |
| CHEMBL6724 | — | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL2324869 | — | Ki | = | 218.0 | nM | 6.66 |
| CHEMBL6919 | — | Ki | = | 223.0 | nM | 6.65 |
| CHEMBL310671 | SACCHARIN | Ki | = | 273.0 | nM | 6.56 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 324.0 | nM | 6.49 |
| CHEMBL224292 | — | Ki | = | 326.0 | nM | 6.49 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 343.0 | nM | 6.46 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL26 | SULPIRIDE | Ki | = | 418.0 | nM | 6.38 |
| CHEMBL328560 | SULTHIAME | Ki | = | 424.0 | nM | 6.37 |
| CHEMBL265674 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL414 | CARZENIDE | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL6753 | — | Ki | = | 595.0 | nM | 6.22 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 613.0 | nM | 6.21 |
| CHEMBL7092 | — | Ki | = | 662.0 | nM | 6.18 |
| CHEMBL6853 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL6633 | — | Ki | = | 685.0 | nM | 6.16 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 685.0 | nM | 6.16 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 711.0 | nM | 6.15 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 722.0 | nM | 6.14 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 741.0 | nM | 6.13 |
| CHEMBL865 | VALDECOXIB | Ki | = | 755.0 | nM | 6.12 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 893.0 | nM | 6.05 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 945.0 | nM | 6.03 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1035.0 | nM | 5.99 |
| CHEMBL266240 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL268439 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL7146 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL2324864 | — | Ki | = | 3540.0 | nM | 5.45 |
| CHEMBL419 | MAFENIDE | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL7087 | — | Ki | = | 3840.0 | nM | 5.42 |
| CHEMBL269122 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL6852 | — | Ki | = | 4220.0 | nM | 5.38 |
| CHEMBL266026 | — | Ki | = | 4650.0 | nM | 5.33 |
| CHEMBL220492 | TOPIRAMATE | Ki | > | 100000.0 | nM | - |
| CHEMBL2324868 | — | Ki | > | 100000.0 | nM | - |