Assay Detail
Functional
CHEMBL3407199
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Antimalarial activity against chloroquine and mefloquine-resistant Plasmodium falciparum Dd2 after 48 hrs by SYBR Green I assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antimalarial evaluation of prodrugs of novel fosmidomycin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.50 | 7.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3403497 | — | — | 1 | 7.56 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 7.04 |
| CHEMBL261371 | — | — | 1 | 6.57 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.52 |
| CHEMBL203125 | FOSMIDOMYCIN | 3.0 | 1 | 6.09 |
| CHEMBL1922604 | — | — | 1 | 6.05 |
| CHEMBL3403498 | — | — | 1 | 5.65 |
| CHEMBL3403499 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3403497 | — | IC50 | = | 27.4 | nM | 7.56 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL261371 | — | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL203125 | FOSMIDOMYCIN | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL1922604 | — | IC50 | = | 893.0 | nM | 6.05 |
| CHEMBL3403498 | — | IC50 | = | 2240.3 | nM | 5.65 |
| CHEMBL3403499 | — | IC50 | - | — | - |