Assay Detail
Binding
CHEMBL3411010
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant macrophage migration inhibitory factor tautomerase activity expressed in Escherichia coli DH5alpha using L-dopachrome methyl ester as substrate incubated for 5 mins prior to substrate addition measured for 2 mins by spectrophotometric analysis
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Macrophage migration inhibitory factor (CHEMBL2085) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.35 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55285 | BENZYL ISOTHIOCYANATE | — | 1 | 6.28 |
| CHEMBL81201 | — | — | 1 | 6.16 |
| CHEMBL3409229 | — | — | 1 | 6.12 |
| CHEMBL2251720 | 1-PHENYLETHYL ISOTHIOCYANATE | — | 1 | 6.00 |
| CHEMBL3409223 | — | — | 1 | 5.96 |
| CHEMBL233248 | ALLYL ISOTHIOCYANATE | 1.0 | 1 | 5.96 |
| CHEMBL3409230 | — | — | 1 | 5.54 |
| CHEMBL3409218 | — | — | 1 | 5.44 |
| CHEMBL48802 | SULFORAPHANE | 3.0 | 1 | 4.96 |
| CHEMBL151649 | PHENETHYLISOTHIOCYANATE | — | 1 | 4.80 |
| CHEMBL3409224 | — | — | 1 | 4.55 |
| CHEMBL3409220 | — | — | 1 | 4.54 |
| CHEMBL3409221 | — | — | 1 | 4.40 |
| CHEMBL3409219 | — | — | 1 | 4.21 |
| CHEMBL2074871 | PHENETHYL ISOCYANATE | — | 1 | - |
| CHEMBL2251721 | BENZYL THIOCYANATE | — | 1 | - |
| CHEMBL3409409 | — | — | 1 | - |
| CHEMBL3409412 | — | — | 1 | - |
| CHEMBL3409228 | — | — | 1 | - |
| CHEMBL3409410 | — | — | 1 | - |
| CHEMBL3409222 | — | — | 1 | - |
| CHEMBL2151314 | — | — | 1 | - |
| CHEMBL3409411 | — | — | 1 | - |
| CHEMBL3409225 | — | — | 1 | - |
| CHEMBL3409226 | — | — | 1 | - |
| CHEMBL3409227 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55285 | BENZYL ISOTHIOCYANATE | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL81201 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3409229 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL2251720 | 1-PHENYLETHYL ISOTHIOCYANATE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3409223 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL233248 | ALLYL ISOTHIOCYANATE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3409230 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL3409218 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL48802 | SULFORAPHANE | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL151649 | PHENETHYLISOTHIOCYANATE | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3409224 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL3409220 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL3409221 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL3409219 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL2074871 | PHENETHYL ISOCYANATE | IC50 | - | — | - | |
| CHEMBL2251721 | BENZYL THIOCYANATE | IC50 | - | — | - | |
| CHEMBL3409409 | — | IC50 | - | — | - | |
| CHEMBL3409412 | — | IC50 | - | — | - | |
| CHEMBL3409228 | — | IC50 | - | — | - | |
| CHEMBL3409410 | — | IC50 | - | — | - | |
| CHEMBL3409222 | — | IC50 | - | — | - | |
| CHEMBL2151314 | — | IC50 | - | — | - | |
| CHEMBL3409411 | — | IC50 | - | — | - | |
| CHEMBL3409225 | — | IC50 | - | — | - | |
| CHEMBL3409226 | — | IC50 | - | — | - | |
| CHEMBL3409227 | — | IC50 | - | — | - |