Assay Detail
Binding
CHEMBL3411100
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human NK1 receptor expressed in CHO cells by luminescence assay in presence of SP peptide
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pA2 | 11 | - | - |
| Kd | 5 | 6.99 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1782139 | — | — | 1 | 8.40 |
| CHEMBL1782141 | — | — | 1 | 7.80 |
| CHEMBL3408519 | — | — | 1 | 6.44 |
| CHEMBL3408520 | — | — | 1 | 6.27 |
| CHEMBL3408518 | — | — | 1 | 6.04 |
| CHEMBL3408737 | — | — | 1 | - |
| CHEMBL3408736 | — | — | 1 | - |
| CHEMBL3408735 | — | — | 1 | - |
| CHEMBL3408734 | — | — | 1 | - |
| CHEMBL3408733 | — | — | 1 | - |
| CHEMBL3408732 | — | — | 1 | - |
| CHEMBL3408731 | — | — | 1 | - |
| CHEMBL3408730 | — | — | 1 | - |
| CHEMBL3408522 | — | — | 1 | - |
| CHEMBL3408521 | — | — | 1 | - |
| CHEMBL1782140 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1782139 | — | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL1782141 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL3408519 | — | Kd | = | 363.08 | nM | 6.44 |
| CHEMBL3408520 | — | Kd | = | 537.03 | nM | 6.27 |
| CHEMBL3408518 | — | Kd | = | 912.01 | nM | 6.04 |
| CHEMBL3408737 | — | pA2 | - | — | - | |
| CHEMBL3408736 | — | pA2 | - | — | - | |
| CHEMBL3408735 | — | pA2 | - | — | - | |
| CHEMBL3408734 | — | pA2 | - | — | - | |
| CHEMBL3408733 | — | pA2 | - | — | - | |
| CHEMBL3408732 | — | pA2 | - | — | - | |
| CHEMBL3408731 | — | pA2 | - | — | - | |
| CHEMBL3408730 | — | pA2 | - | — | - | |
| CHEMBL3408522 | — | pA2 | - | — | - | |
| CHEMBL3408521 | — | pA2 | - | — | - | |
| CHEMBL1782140 | — | pA2 | - | — | - |