Assay Detail
Binding
CHEMBL3411299
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Inhibition of human ROCK2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK peptide substrate, ATP and [gamma33P]ATP
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.79 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3410022 | — | — | 1 | 7.35 |
| CHEMBL1951443 | — | — | 1 | 7.05 |
| CHEMBL1951349 | — | — | 1 | 6.88 |
| CHEMBL1951441 | — | — | 1 | 6.78 |
| CHEMBL1951350 | — | — | 1 | 6.61 |
| CHEMBL3410050 | — | — | 1 | 6.34 |
| CHEMBL3407526 | — | — | 1 | 6.11 |
| CHEMBL3410026 | — | — | 1 | 6.01 |
| CHEMBL1951344 | — | — | 1 | 5.87 |
| CHEMBL1951346 | — | — | 1 | 5.79 |
| CHEMBL3410037 | — | — | 1 | 5.79 |
| CHEMBL3410038 | — | — | 1 | 5.72 |
| CHEMBL3410033 | — | — | 1 | 5.64 |
| CHEMBL3410028 | — | — | 1 | 5.63 |
| CHEMBL3410031 | — | — | 1 | 5.59 |
| CHEMBL3410047 | — | — | 1 | 5.49 |
| CHEMBL3410039 | — | — | 1 | 5.49 |
| CHEMBL3410040 | — | — | 1 | 5.48 |
| CHEMBL3410042 | — | — | 1 | 5.36 |
| CHEMBL3410029 | — | — | 1 | 5.27 |
| CHEMBL3410023 | — | — | 1 | 5.25 |
| CHEMBL3410045 | — | — | 1 | 5.23 |
| CHEMBL3410036 | — | — | 1 | 5.18 |
| CHEMBL3410030 | — | — | 1 | 5.18 |
| CHEMBL3410027 | — | — | 1 | 5.15 |
| CHEMBL3410044 | — | — | 1 | 5.05 |
| CHEMBL3410041 | — | — | 1 | 4.95 |
| CHEMBL3410025 | — | — | 1 | - |
| CHEMBL3410056 | — | — | 1 | - |
| CHEMBL3410055 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3410022 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1951443 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1951349 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL1951441 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL1951350 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL3410050 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL3407526 | — | IC50 | = | 781.0 | nM | 6.11 |
| CHEMBL3410026 | — | IC50 | = | 976.0 | nM | 6.01 |
| CHEMBL1951344 | — | IC50 | = | 1365.0 | nM | 5.87 |
| CHEMBL1951346 | — | IC50 | = | 1608.0 | nM | 5.79 |
| CHEMBL3410037 | — | IC50 | = | 1605.0 | nM | 5.79 |
| CHEMBL3410038 | — | IC50 | = | 1898.0 | nM | 5.72 |
| CHEMBL3410033 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL3410028 | — | IC50 | = | 2358.0 | nM | 5.63 |
| CHEMBL3410031 | — | IC50 | = | 2572.0 | nM | 5.59 |
| CHEMBL3410047 | — | IC50 | = | 3219.0 | nM | 5.49 |
| CHEMBL3410039 | — | IC50 | = | 3239.0 | nM | 5.49 |
| CHEMBL3410040 | — | IC50 | = | 3339.0 | nM | 5.48 |
| CHEMBL3410042 | — | IC50 | = | 4357.0 | nM | 5.36 |
| CHEMBL3410029 | — | IC50 | = | 5421.0 | nM | 5.27 |
| CHEMBL3410023 | — | IC50 | = | 5570.0 | nM | 5.25 |
| CHEMBL3410045 | — | IC50 | = | 5932.0 | nM | 5.23 |
| CHEMBL3410030 | — | IC50 | = | 6652.0 | nM | 5.18 |
| CHEMBL3410036 | — | IC50 | = | 6565.0 | nM | 5.18 |
| CHEMBL3410027 | — | IC50 | = | 7083.0 | nM | 5.15 |
| CHEMBL3410044 | — | IC50 | = | 8940.0 | nM | 5.05 |
| CHEMBL3410041 | — | IC50 | = | 11270.0 | nM | 4.95 |
| CHEMBL3410034 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3410032 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3410043 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3410046 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3410035 | — | IC50 | - | — | - | |
| CHEMBL3410048 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3410049 | — | IC50 | - | — | - | |
| CHEMBL3410024 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3410051 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3410052 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3410053 | — | IC50 | - | — | - | |
| CHEMBL3410054 | — | IC50 | - | — | - | |
| CHEMBL3410055 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3410056 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3410025 | — | IC50 | > | 10000.0 | nM | - |